Cambridge Epigenetix (CEGX) is a life sciences tools and analytics company, founded in 2012, by Professor Sir Shankar Balasubramanian FRS and Dr. Bobby Yerramilli-Rao. CEGX is seeking to revolutionize genome sequencing through a proprietary technology platform that has the potential to deliver step changes in both the type of information that can be generated from DNA and the cost at which it is gathered. This is bringing closer the day when advanced medicines, diagnostics and personalized treatments become a reality for all
The Cambridge Epigenetix platform, extends the information content of sequencing by unambiguously identifying five letters of DNA – four genetic bases (A-T-C-G) plus methylated cytosine (5mC or 5hmC). This information is captured at single base resolution from very small amounts of DNA, and with an accuracy that exceeds other known methods. This approach can significantly reduce sequencing costs whilst preserving complexity, facilitating rapid and lower cost data analysis.
Epigenetic marks are a vital source of biological information to enable the next generation of diagnostics including those for early cancer detection. The laboratory component of CEGX’s product is already in manufacture and kits, with associated software, are expected to be available in early 2022. This will be followed by the launch of additional multiomic products from this platform, the next being a 6-letter kit’ (adding the epigenetic marker hydroxymethylcytosine). CEGX is developing further technology platforms supported by their extensive IP portfolio.
In late 2021, the JIMCO Life Sciences Fund participated in Cambridge Epigenetix’s US$ 88 million Series D funding round.
Easily integrating into existing sequencers, the company’s products allow the user to see at-a-glance genomic and epigenetic information. Such information can be employed to detect, diagnose, treat and understand disease. Based in Cambridge, UK, the company is founded by a pioneer in DNA sequencing intent on leading the next great leap forward in genomics.
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